Aim: To determine whether the disability and the quality of life are related with the metabolic control or depression and anxiety levels in patients with type 2 diabetes mellitus (DM). Materials and Methods: Eighty-three outpatients with DM, were assessed using a sociodemographic and medical data form, the Hospital Anxiety and Depression Scale (HAD-A and HAD-D), the Brief Disability Questionnaire (BDQ), and the Brief Form of the Quality of Life Scale (WHOQOL-BREF-TR). Results: The mean age of the sample (67 females and 16 males) was 50.92±8.42 (range: 23-70) years. Thirty-one patients (37.3%) scored above the cut-off point of HAD-D, and 16 patients (19.3%) scored above the threshold in HAD-A. The disability was found significantly higher in diabetes patients with high levels of both HAD-D and HAD-A. A positive psychiatric history was associated with higher disability and worsening in all domains of quality of life. Conclusion: Disability should be expected in type 2 diabetes patients with high levels of depression and anxiety. For the optimum treatment and healthcare conditions, psychiatric interventions may be useful in improving the quality of life and in reducing the disability.