THE EFFECTS OF PROPOFOL CONCENTRATION ON PROPOFOL INJECTION PAIN
Hüseyin ŞEN, Ali SIZLAN, Ömer YANARATEŞ, Salim DOĞRU, Mehmet MUTLU, Sezai ÖZKAN, Güner DAĞLI
Özet
Recent attempts have been made to decrease propofol induced pain either with pharmacologic ornonpharmacologic methods. The aim of this study was to evaluate the effect of free propofol concentration onpropofol injection pain by using two different standard propofol solutions. One hundred patients (ASA-I/II, agedbetween 20-65 years) were randomized into two groups. In group 1(n=50), we used propofol with a concentrationof 10 mg/mL (solution with 1%, Fresenius) and in group 2(n=50) we used propofol with a concentration of 20mg/mL (solution with 2%, Fresenius). The amounts of free propofol were 18 mg/L and 36 mg/L in group 1 and 2,respectively. Pain during induction with propofol was scored using a 4-point verbal rating scale. Verbal ratingscale (VRS) scores of the patients are given in Tables-3. VRS scores were lower in group 1 when compared withgroup 2 (p<0.001) in all measurements. We did not observe flushing, rash, urticaria, conjuctival congestion,bradycardia and arrhythmia in any patient and there were no other serious side effects during the study. In thelight of our study, we may conclude that propofol injection pain depends on the amount of free propofol in theaqueous phase. In order to prevent this injection pain, there is need for propofol products with lowerconcentrations. We believe that such products may be much more convenient and cost-effective when comparedwith other attempts (i.e. addition of other solutions or drugs) to decrease propofol injection pain. (Anatol J ClinInvestig 2009:3(2);127-130).
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