BAC K G R O U N D The aim of the present study was to investigate the hemodynamic effects of left ventriculography performed with Ioxaglate and its clinical implications. M ET H O D S One hundred consecutive patients who underwent routine coronary angiography were enrolled in the study. The pig-tail catheter was placed in the left ventricle. After stabilizing the position of catheter, it was flushed before left ventricular pressures were recorded. Twenty-four ml of Ioxaglate (Hexabrix, 320 mg/ml) was injected with 600 psi pressure and 16 ml/sec rate for left ventriculography. After left ventriculography, pig-tail catheter was flushed and left ventricular pressures were recorded again. Left ventricular pressures before and after ventriculography were compared. All patients were followed-up for clinical events. R E S U LT S The mean age of study population was 61±11. Coronary angiography was normal in 18 patients. Both systolic and diastolic pressures significantly decreased in all patients after ventriculography. The decrease in diastolic pressure was not significant in patient with normal coronary angiography and impaired left ventricular functions subgroups. No major cardiac events and heart failure was observed during clinical follow-up period. Only one patient had dyspnea which was relieved with intravenous diuretic. CO N C L U S I O N S The significant decrease in left ventricular pressures was observed after left ventriculography. We did not found any significant decrease in diastolic pressure in patients with impaired left ventricular function and without coronary artery disease. Decrease in left ventricular pressures did not cause any severe clinical outcomes. Ioxaglate seems to be a safe agent for ventriculography.