B AC K G R O U N D A th er o s cl er osis is infl a mm atory progress and in case of acute cor onary syndrome inflammat ion has been increased. The progn o stic values of leuk o c yte count (WBC), Creactive protein (CRP) and tumor necrosis factor-α ( TNF-α) were eval u ated in the short-term period of AMI. M ET H O D S We included 156 patients with AMI. Blood samples were taken during first evaluation. Cardiac death, reinfarction and postinfarction angina were accepted as the endpoints defined as major cardiac event (MACE) during the first month following AMI. Clinical features of two groups that were with and without MACE were compared using the chi-square test and the Student’t t test was used to compare for the labarotory findings. The correlation between WBC, CRP and MACE was evaluated by using Spearman’s correlation analysis technique. R E S U LT S The levels of WBC, CRP were higher in pat ients with MACE than in pat ients without MACE (14.12±2.86 mm3 vs 9 . 5 1 ± 4 . 8 1 m m3, p=0.01), (23.23±11.54 mg/L vs 16.10±15.09 mg/L, p=0.03) but the level of TNF-α was slightly lower (5.98±3.93, 6.55±4.96 pg/ml, p>0.05 respectively). There was a correlation betw een elevated WBC and CRP levels and short-term prognosis of the post infarction period, but no with the levels of TNF-α. In subgroup analysis, there was corr elat ion betw een risk factors and MACE, except sex. Also, we detected relat ion among high levels of WBC, CRP and MACE (r=0.88, p=0.041). CO N C L U S I O N S We determined that elevated WBC and CRP in AMI may be poor prognosis indicators in short-term following AMI.